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Test Code PBU Lead, 24 Hour, Urine

Reporting Name

Lead, 24 Hr, U

Useful For

Detecting clinically significant lead exposure

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Urine

Specimen Required

Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert

Submission Container/Tube: Plastic, 10-mL urine tube (Supply T068) or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information:

1. 24-Hour volume is required.

2. See Urine Preservatives in Special Instructions for multiple collections.

3. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

 

Urine Preservative Collection Options

Ambient

Yes

Refrigerated

Preferred

Frozen

Yes

6N HCl

Yes

50% Acetic Acid

Yes

Na2CO3

No

Toluene

Yes

6N HNO3

Yes

Boric Acid

No

Thymol

No

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-4 mcg/specimen

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Friday; 3 p.m.-9 p.m.; Saturday; 8 a.m.-3 p.m.; Continuously

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83655

LOINC Code Information

Result ID Reporting Name LOINC Code
31085 Lead, 24 Hr, U 5677-0
TM83 Collection Duration 13362-9
VL84 Urine Volume 3167-4
866 Pb Concentration 20625-0

Clinical Information

Increased urine lead excretion rate indicates significant lead exposure. Measurement of urine lead excretion rate before AND after chelation therapy has been used as an indicator of lead exposure. An increase in lead excretion rate in the post chelation specimen of up to 6 times the rate in the prechelation specimen is normal. Blood lead is the best clinical correlate of toxicity.

 

For additional information, see PBBD / Lead with Demographics, Blood.

Interpretation

Urinary excretion of <125 mcg of lead per 24 hours is not associated with any significant lead exposure.

 

Urinary excretion >125 mcg of lead per 24 hours is usually associated with pallor, anemia, and other evidence of lead toxicity.

Analytic Time

1 day

Specimen Retention Time

14 days

Reject Due To

Hemolysis

NA

Lipemia

NA

Icterus

NA

Other

NA