Test Code PBU Lead, 24 Hour, Urine
Reporting NameLead, 24 Hr, U
Detecting clinically significant lead exposure
Performing LaboratoryMayo Medical Laboratories in Rochester
Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 10-mL urine tube (T068) or a clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 10 mL
1. Collect urine for 24 hours.
2. Refrigerate specimen within 4 hours of completion of 24-hour collection.
3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.
1. 24-Hour volume is required.
2. See Urine Preservatives in Special Instructions for multiple collections.
3. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.
Specimen Minimum Volume
Specimen Stability Information
|Urine||Refrigerated (preferred)||28 days|
Reference values apply to all ages.
Day(s) and Time(s) Performed
Monday through Friday; 3 p.m.-9 p.m.; Saturday; 8 a.m.-3 p.m.; Continuously
Test ClassificationThis test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
CPT Code Information
LOINC Code Information
|Test ID||Test Order Name||Order LOINC Value|
|PBU||Lead, 24 Hr, U||In Process|
|Result ID||Test Result Name||Result LOINC Value|
|31085||Lead, 24 Hr, U||5677-0|
Increased urine lead excretion rate indicates significant lead exposure. Measurement of urine lead excretion rate before AND after chelation therapy has been used as an indicator of lead exposure. An increase in lead excretion rate in the post chelation specimen of up to 6 times the rate in the prechelation specimen is normal. Blood lead is the best clinical correlate of toxicity.
For additional information, see PBDB / Lead with Demographics, Blood.
Urinary excretion of <125 mcg of lead per 24 hours is not associated with any significant lead exposure.
Urinary excretion >125 mcg of lead per 24 hours is usually associated with pallor, anemia, and other evidence of lead toxicity.
Analytic Time1 day
Specimen Retention Time14 days
Reject Due To
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)