Test Code SGSU Synthetic Glucocorticoid Screen, Urine
Reporting NameSynthetic Glucocorticoid Screen, U
Confirming the presence of the listed synthetic glucocorticoids (see Interpretation)
Confirming the cause of secondary adrenal insufficiency
This assay does not detect fluticasone propionate.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Performing LaboratoryMayo Medical Laboratories in Rochester
Container/Tube: Plastic, 10-mL urine tube (Supply T068)
Specimen Volume: 5 mL
1. Collect a random urine specimen.
2. No preservative.
Specimen Minimum Volume
Specimen Stability Information
|Urine||Frozen (preferred)||14 days|
Beclomethasone dipropionate: 0.10 mcg/dL
Betamethasone: 0.10 mcg/dL
Budesonide: 0.10 mcg/dL
Dexamethasone: 0.10 mcg/dL
Fludrocortisone: 0.10 mcg/dL
Flunisolide: 0.10 mcg/dL
Fluorometholone: 0.10 mcg/dL
Megestrol acetate: 0.10 mcg/dL
Methylprednisolone: 0.10 mcg/dL
Prednisolone: 0.10 mcg/dL
Prednisone: 0.10 mcg/dL
Triamcinolone 0.30 mcg/dL
Triamcinolone acetonide: 0.10 mcg/dL
Values for normal patients not taking these synthetic glucocorticoids should be less than the cutoff concentration (detection limit).
Day(s) and Time(s) Performed
Wednesday, 8 a.m.
Test ClassificationThis test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.
CPT Code Information
LOINC Code Information
|Result ID||Reporting Name||LOINC Code|
Synthetic glucocorticoids are widely used and have important clinical utility both as anti-inflammatory and immunosuppressive agents. The medical use of these agents, as well as their surreptitious use, can sometimes lead to a confusing clinical presentation. Patients exposed to these steroids may present with clinical features of Cushing syndrome, but with suppressed cortisol levels and evidence of hypothalamus-pituitary-adrenal axis suppression.
This test screens for and quantitates, if present, the following synthetic glucocorticoids: beclomethasone dipropionate, betamethasone, budesonide, dexamethasone, fludrocortisone, flunisolide, fluorometholone, megestrol acetate, methylprednisolone, prednisolone, prednisone, triamcinolone, and triamcinolone acetonide.
The presence of synthetic glucocorticoids in urine indicates current or recent use of these compounds. Since several of these compounds exceed the potency of endogenous cortisol by 1 or more orders of magnitude, even trace levels may be associated with Cushingoid features.
Analytic Time3 days
Specimen Retention Time3 months
Reject Due To