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Test Code SHSTO Histoplasma Antibody, Serum

Reporting Name

Histoplasma Ab, S

Useful For

Aiding in the diagnosis of active histoplasmosis

Method Name

Complement Fixation (CF)/Immunodiffusion

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum

Specimen Required

Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Mycelial by CF: negative (positives reported as titer)

Yeast by CF: negative (positives reported as titer)

Antibody by immunodiffusion: negative (positives reported as band present)

Day(s) and Time(s) Performed

Monday through Friday; 9:30 a.m.

Test Classification

This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86698 x 3

LOINC Code Information

Result ID Reporting Name LOINC Code
15121 Histoplasma Mycelial 20573-2
15122 Histoplasma Yeast 20574-0
15123 Histoplasma Immunodiffusion 5218-3

Clinical Information

Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched with bird droppings.

 

The usual disease is self-limited, affects the lungs, and is asymptomatic.

 

Chronic cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially in young children and in immunosuppressed patients.

Interpretation

Complement fixation (CF) titers ≥1:32 indicate active disease. A rising CF titer is associated with progressive infection.

 

Positive immunodiffusion test results supplement findings of the CF test. The simultaneous appearance of both H and M precipitin bands indicates active histoplasmosis. The M precipitin band alone indicates early or chronic disease or a recent histoplasmosis skin test.

 

Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.

Analytic Time

2 days

Specimen Retention Time

14 days

Reject Due To

Hemolysis

Mild OK;Gross reject

Lipemia

Mild OK;Gross reject

Icterus

NA

Other

NA