Test Code SHSTO Histoplasma Antibody, Serum
Reporting NameHistoplasma Ab, S
Aiding in the diagnosis of active histoplasmosis
Performing LaboratoryMayo Medical Laboratories in Rochester
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Forms: If not ordering electronically, complete, print, and send a Neurology Test Request Form-General (T732) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/neurology-request-form.pdf)
Specimen Minimum Volume
Specimen Stability Information
|Serum||Refrigerated (preferred)||14 days|
Mycelial by CF: negative (positives reported as titer)
Yeast by CF: negative (positives reported as titer)
Antibody by immunodiffusion: negative (positives reported as band present)
Day(s) and Time(s) Performed
Monday through Friday; 9:30 a.m.
Test ClassificationThis test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.
CPT Code Information
86698 x 3
LOINC Code Information
|Result ID||Test Result Name||Result LOINC Value|
Histoplasma capsulatum is a soil saprophyte that grows well in soil enriched with bird droppings.
The usual disease is self-limited, affects the lungs, and is asymptomatic.
Chronic cavitary pulmonary disease, disseminated disease, and meningitis may occur and can be fatal, especially in young children and in immunosuppressed patients.
Complement fixation (CF) titers ≥1:32 indicate active disease. A rising CF titer is associated with progressive infection.
Positive immunodiffusion test results supplement findings of the CF test. The simultaneous appearance of both H and M precipitin bands indicates active histoplasmosis. The M precipitin band alone indicates early or chronic disease or a recent histoplasmosis skin test.
Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.
Analytic Time2 days
Specimen Retention Time14 days
Reject Due To
Mild OK;Gross reject
Mild OK;Gross reject
Complement Fixation (CF)/Immunodiffusion