Sign in →

Test Code 1DIS Human Leukocyte Antigens (HLA) A-B-C Disease Association Typing Low Resolution, Blood


Specimen Required


Container/Tube: Yellow top (ACD solution A or B)

Specimen Volume: 6 mL

Collection Instructions: Send whole blood in original tube. Do not aliquot.

Additional Information: Specimen acceptability is based on extracted DNA concentration and not sample age.


Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.

Useful For

Determining class I human leukocyte antigens (HLA) on specimens for those patients who have become refractory to platelet transfusions and identify potential disease associations or markers for drug hypersensitivity

Method Name

Polymerase Chain Reaction (PCR)/Next-Generation Sequencing (NGS)

Reporting Name

HLA-A-B-C DisAssoc Typing LowRes,B

Specimen Type

Whole Blood ACD

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood ACD Ambient (preferred)
  Refrigerated 

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Clinical Information

Human leukocyte antigens (HLA) are regulators of the immune response. HLA class I typing is used to identify HLA-matched platelets for alloimmunized refractory patients and identify presence of HLA antigens associated with a number of diseases or as drug hypersensitivity markers Class I HLA antigens include A, B, and C loci. This assay is designed to provide low-to-medium resolution for HLA class I typing (A, B, C). Low-to-medium resolution defines the typing at the antigen level (first field). This contrasts with high-resolution typing, which defines typing at the allele (molecular) level (second field or higher).

Reference Values

Not applicable

Interpretation

Interpretation depends on the rationale for ordering the test.

Day(s) Performed

Monday, Thursday

Report Available

7 to 17 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

81372

LOINC Code Information

Test ID Test Order Name Order LOINC Value
1DIS HLA-A-B-C DisAssoc Typing LowRes,B 96629-1

 

Result ID Test Result Name Result LOINC Value
1DA02 ABC DisAssoc Comment 96625-9
1DA03 A - 1 Equivalent 13298-5
1DA04 A - 2 Equivalent 13298-5
1DA05 A - 1 Molecular 78014-8
1DA06 A - 2 Molecular 78014-8
1DA07 B - 1 Equivalent 13299-3
1DA08 B - 2 Equivalent 13299-3
1DA09 B - 1 Molecular 78015-5
1DA10 B - 2 Molecular 78015-5
1DA11 Bw - 1 Equivalent 96633-3
1DA12 Bw - 2 Equivalent 96633-3
1DA13 C - 1 Equivalent 13302-5
1DA14 C - 2 Equivalent 13302-5
1DA15 C - 1 Molecular 96636-6
1DA16 C - 2 Molecular 96636-6
LRTM1 Test Method 85069-3

Specimen Retention Time

14 days