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Test Code FIBAG Fibrinogen Antigen, Plasma

Useful For

Evaluation of fibrinogen deficiency

 

Measuring fibrinogen in patients with elevated plasma levels of fibrin degradation products, patients receiving heparin, and in patients with antibodies to thrombin (following surgical use of topical bovine thrombin)

 

Identifying afibrinogenemia, hypofibrinogenemia, and dysfibrinogenemia when ordered in combination with fibrinogen activity (FIBTP / Fibrinogen, Plasma)

Method Name

Immunoturbidimetric

Reporting Name

Fibrinogen Antigen, P

Specimen Type

Plasma Na Cit


Specimen Required


Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube: Light-blue top (3.2% sodium citrate at 9:1 ratio)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot plasma into plastic vial. Send refrigerated.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Clinical Information

Fibrinogen (clotting factor I) is an essential protein responsible for blood clot formation. In the final step of the coagulation cascade, thrombin converts soluble fibrinogen into insoluble fibrin strands that crosslink and form a clot.

 

Fibrinogen is synthesized in the liver and has a biological half-life of 3 to 5 days in the circulating plasma. Fibrinogen deficiencies can be congenital or acquired and lead to prolonged coagulation times. Isolated fibrinogen deficiency is an extremely rare inherited coagulation disorder.

 

Acquired fibrinogen deficiency is most commonly caused by, acute or decompensated intravascular coagulation and fibrinolysis. Other causes of fibrinogen deficiency include advanced liver disease, L-asparaginase therapy, or fibrinolytic agents (eg, streptokinase, urokinase, tissue plasminogen activator).

Reference Values

≥18 years: 196-441 mg/dL

Reference values have not been established for patients that are less than 18 years of age.

Interpretation

This method measures the total amount of fibrinogen protein (ie, fibrinogen antigen) present in the plasma.

 

Adequate fibrinogen antigen levels in a context of low fibrinogen activity suggests a dysfibrinogenemia.

 

Fibrinogen antigen levels lower than 100 mg/dL are associated with an increased risk of bleeding.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Specimen Retention Time

7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85385

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FIBAG Fibrinogen Antigen, P 3256-5

 

Result ID Test Result Name Result LOINC Value
FIBAG Fibrinogen Antigen, P 3256-5