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Test Code HEXP Iohexol, Plasma

Reporting Name

Iohexol, P

Useful For

Determining glomerular filtration rate in plasma specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma Heparin


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Green top (heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot plasma into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Heparin Refrigerated (preferred) 7 days
  Frozen  35 days
  Ambient  7 days

Reference Values

Not applicable

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HEXP Iohexol, P 93974-4

 

Result ID Test Result Name Result LOINC Value
61713 Iohexol, P 93974-4

Clinical Information

The assessment of glomerular filtration rate (GFR) is an important parameter of kidney function utilized by clinicians in the care of patients with varying kidney diseases, and for clinical research when precise assessment of kidney function is necessary. The GFR is the sum of all the filtration rates of the individual nephrons within the kidney and, as such, reflects the number of functioning nephrons.

 

Plasma concentrations of iohexol can be used for measurement of GFR through multiple plasma iohexol determinations following an intravenous bolus injection of iohexol (plasma disappearance) or following a continuous infusion (or subcutaneous injection) of iohexol when used in conjunction with urine iohexol determinations (urinary clearance; HEXU / Iohexol, Timed Collection, Urine).

Interpretation

Low glomerular filtration rate (GFR) values indicate abnormal kidney function, which may be either reversible/transient or irreversible/permanent. GFR tends to decline with age.

Report Available

3 to 4 days

Specimen Retention Time

7 days

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.