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HelpTest Code RCVBS Recoverin-IgG Antibody, Immunoblot, Serum
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluating patients with suspected paraneoplastic retinopathy accompanying small cell carcinoma
Method Name
Immunoblot (IB)
Reporting Name
Recoverin Immunoblot, SSpecimen Type
SerumSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Clinical Information
Patients with recoverin autoimmunity present with insidious onset vision change, often night-vision loss, floaters, and constricted vision, that can rapidly progress to blindness. On ophthalmologic examination, there are features of non-inflammatory retinopathy; retinal and optic nerve head pallor/atrophy, constricted visual fields and flat electroretinogram (ERG), but without anterior chamber disease, which is encountered with CRMP-5 paraneoplastic ophthalmitis. Small cell (pulmonary or extrapulmonary) or neuroendocrine carcinoma should be sought. Trials of immunotherapy could be attempted to improve vision, though generally this is not successful.
Reference Values
Negative
Interpretation
Seropositivity is consistent with a diagnosis of paraneoplastic retinopathy. Small cell carcinoma (pulmonary or extrapulmonary) and neuroendocrine carcinoma should be considered.
Specimen Retention Time
28 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84182
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RCVBS | Recoverin Immunoblot, S | 83003-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 610009 | Recoverin Immunoblot, S | 83003-4 |
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.
Day(s) Performed
Monday through Friday